Locarno to Andermatt.
This journey requires two changes of train. The first of these is at Bellinzona where you change onto the train which will take you through the original Gotthard Tunnel (not to be confused with the newer Gotthard Base Tunnel).
This second train almost connects with the main line through the Alps. It actually stops at Goschenen though, where you can catch a third train which makes the short journey to Andermatt on the main rail route.
Web resources for this route:
Official Train Operator: www.sbb.ch (English version)
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[photo credit: switzerland-tour.com]